Police are appealing for witnesses after a crash near Anstey.
It happened Friday at around 5.30pm in Cropston Road, between the villages of Cropston and Anstey – near to the junction with Waterfield Road.
The three vehicles reportedly involved were a red Skoda Fabia, a black Range Rover and a van.
The driver of the Fabia, a woman in her 50s, was taken to the Queen’s Medical Centre. She remains in hospital in a serious condition.
The drivers of the other two vehicles did not require hospital treatment.
Detective Constable Louise McMahon from the force’s Serious Collision Investigation Unit, said: “I would like to speak to anyone who witnessed the incident or has dash cam footage of the vehicles either before the collision or of the collision itself.”
New rules in place for bird keepers in Leicestershire
£3m upgrade for Council’s passenger transport fleet
Video technology sees faster treatment for stroke patients in Leicestershire
East Midlands Airport Assisted Travel service wins national award
Man charged after fire in Loughborough
Man sentenced after Loughborough stabbing left victim seriously injured
