The 14-year-old girls are missing from the Glenfield area.
It is believed that Lexi Moore and Rhimaya Liburd-Foster are together and may have travelled to Nottingham.
Both their families and the police are concerned for their welfare.
Lexi is 5ft 2ins tall and of a slim build, with dark hair.
Rhimaya is 5ft 10ins tall, mixed race and has shoulder-length, straight hair which has been combed out.
It is not known what they are wearing.
Anyone who has seen the girls, or knows of their whereabouts, is asked to call 101, quoting incident 745 of 31 July.
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