Buses replace trains between Nottingham and Leicester on Saturday 4 and Sunday 5 October.
A bridge is being demolished this weekend, and train lines between Nottingham and Leicester will be closed.
Buses will replace trains between Nottingham and Leicester.
Network Rail will be carrying out the demolition of Flying Arch bridge at Sutton Bonington, near Loughborough.
Network Rail has said that: "The bridge was due to be demolished to make way for overhead line equipment as part of Midland Main Line electrification. While this major programme has been paused, it has been agreed with the Department for Transport to proceed with the bridge demolition, which will mean the route is ready if electrification resumes in the future.
"This work will also provide the necessary clearance for larger freight trains to run on this section of the line, helping to move more goods by rail instead of road – reducing congestion and cutting carbon emissions."
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